【36-A. Dr. Jens B.Bosse】

◼ Research Field
  - The Bosse Lab investigates the molecular architecture and dynamics of virus–host interactions, with a particular focus on herpesvirus infection. We combine structural systems virology, advanced imaging, and AI-driven computational modeling to understand how viral proteins assemble, remodel cellular environments, and drive key steps of the infection cycle.

Our work spans scales—from high-resolution structural predictions (AlphaFold-Multimer, cryo-EM/CLEM) to live-cell and super-resolution microscopy that captures viral processes in real time. We map viral interactomes, identify molecular interfaces, and use mutational energetics and binder design to test mechanistic hypotheses directly in living cells.

By integrating computational predictions with quantitative imaging, cell-free interaction assays, and functional virology, the Bosse Lab aims to uncover conserved principles of viral replication, identify vulnerabilities in viral machineries, and ultimately enable rational design of antiviral strategies.

◼ Required Research Field of Study
  - Computational Biology, Structural Biology, Virology, Cell Biology

◼ Description of Research Activities During the Program
  - Computational and/or lab work depending on students interests

◼ Research Equipment or Software to be Used
  - Python, structural prediction software, molecular biology/virology equipment depending on students choice

◼ Website
  - www.bosse-lab.org
  - www.virusfolds.org
  - www.herpesfolds.org

【36-B. Dr. Oliver Jäckle-Tietjen】

◼ Research Field
  - Infectious diseases are a global threat that costs many lives and have a significant impact on society. The key to effectively fighting infectious diseases is gaining a detailed understanding of the underlying molecular mechanisms of various pathogens. At the Centre for Structural Systems Biology (CSSB), scientists study the structure and function of pathogens, such as viruses, bacteria, parasites and amyloids, and their interactions with the host. In the process, CSSB’s fundamental research seeks to enable the identification of targets for interventions.

CSSB is a joint initiative of ten leading research institutions in Germany that are dedicated to advancing molecular infection biology. CSSB serves as a collaborative research hub, integrating cutting-edge methods such as structural biology, artificial intelligence and multi-modal imaging. CSSB’s state-of-the-art scientific infrastructure includes four core facilities: for  
i) protein production, ii) sample preparation, characterization & high-throughput crystallization, iii) advanced light and fluorescence microscopy, and iv) cryo-EM. Centrally located on the Science City Hamburg-Bahrenfeld campus, CSSB’s infrastructures are complemented by direct access to DESY’s X-ray beamlines, enabling our scientist to use a sophisticated combination of structural biology approaches.

◼ Required Research Field of Study
  - Biology, Biochemistry, Chemistry, Microbiology, Molecular Life Sciences, or a related field

◼ Description of Research Activities During the Program
  - Work on innovative research projects in molecular structural infection biology

◼ Research Equipment or Software to be Used
  - tba

◼ Website
  - https://www.cssb-hamburg.de/