【36-B. Hannover Medical School at CSSB Hamburg - Dr. Jens B. Bosse】

◼ Research Field
  - The Bosse Lab investigates the molecular architecture and dynamics of virus–host interactions, with a particular focus on herpesvirus infection. We combine structural systems virology, advanced imaging, and AI-driven computational modeling to understand how viral proteins assemble, remodel cellular environments, and drive key steps of the infection cycle.

Our work spans scales—from high-resolution structural predictions (AlphaFold-Multimer, cryo-EM/CLEM) to live-cell and super-resolution microscopy that captures viral processes in real time. We map viral interactomes, identify molecular interfaces, and use mutational energetics and binder design to test mechanistic hypotheses directly in living cells.

By integrating computational predictions with quantitative imaging, cell-free interaction assays, and functional virology, the Bosse Lab aims to uncover conserved principles of viral replication, identify vulnerabilities in viral machineries, and ultimately enable rational design of antiviral strategies.

◼ Required Research Field of Study
  - Computational Biology, Structural Biology, Virology, Cell Biology

◼ Description of Research Activities During the Program
  - Computational and/or lab work depending on students interests

◼ Research Equipment or Software to be Used
  - Python, structural prediction software, molecular biology/virology equipment depending on students choice

◼ Website
  - www.bosse-lab.org
  - www.virusfolds.org
  - www.herpesfolds.org